Sildenafil

Medicine for real men

Each medication has the active substance through which the drug somehow affects the human body. It is developed by scientists for some time in order then to make people good. For men, the most important problem that can affect their virility, is erectile dysfunction. In order to treat the disorder created by a huge amount of drugs that are more or less help men deal with erectile dysfunction. To date, the best drug that affects the male reproductive system is Viagra. Its active ingredient is sildenafil citrate, who has a direct effect on the blood supply to the penis, which is intended to make a full sexual intercourse. This drug is used, as already mentioned, in violation of an erection. It has the same way, no doubt, some side effects and contraindications, because this drug is a synthetic, and all that is made of synthetics has side effects. So, sildenafil citrate is undesirable to use if there is hypersensitivity to the drug, if at the same time the patient is being treated with drugs from the group of nitrates. Just do not need to take the drug if the patient has a deformity of the penis, because it may cause the mechanism of action of sildenafil citrate, and then the effect will be quite different.

The drug, which contains the active ingredient sildenafil citrate, and which is intended to combat impotence, taken orally 1 hour prior to the alleged sexual intercourse in order to increase blood flow to the genitals and create all necessary conditions for the erection of the necessary . The drug, which contains the active ingredient sildenafil citrate is recommended to use 1 time a day, in order to avoid overdose. The dosage can be adjusted from 25 mg to 100 mg, depending on how the drug affects the human body and how it performs its function directly. It should be noted that sildenafil citrate was originally developed as the active agent to improve blood flow in one of the layers of the heart muscle, or rather to say, in the myocardium. Clinical trials have shown that sildenafil citrate has minimal effect on the myocardium, but also maximizes the blood flow to the organs of the pelvis, where the sexual organs of men. Thus, it was decided to use this active ingredient in this direction. Now it is part of the well-known drug that comes in the form of tablets, coated with a gelatin shell, in order to help in the erection disorder of the male sex.

Sildenafil citrate - your best friend against erectile dysfunction

Sildenafil citrate is the active ingredient of many drugs to combat erectile dysfunction. Originally proposed as a matter of cardiovascular means, but as it turned Sildenafil citrate was not effective. Some male patients, who received the drug, have noticed increased sexual potency. After such an effect of medical industry professionals have begun research and testing of the drug towards the treatment of erectile problems.

The drug effect on male potency was confirmed, and received a medical Sildenafil citrate used to combat erectile dysfunction. The mechanism of action of a medicinal product is still not fully investigated. If we consider the drug from the perspective of biochemistry, the basic meaning of sildenafil is currently in the ability to selectively inhibit the activity of the enzyme phosphodiesterase type V, which carries the inactivation of cyclic guanosine monophosphate (c-GMP). Guanosine monophosphate, in turn, serves to relax the smooth muscles of the cavernous body and improves blood flow to the penis.

Sildenafil has no direct effect on vascular relaxation of the corpus cavernosum, but increases the effect of vasodilatation, the release of nitric oxide (NO) at the time of sexual stimulation. Physiologically, the substance acts as a spinal cord stimulation. Since then, the drug began to be used to treat disorders of potency associated with lesions of the spinal cord. Sildenafil citrate was an effective tool to combat erectile dysfunction. Dosage form of the drug - pills. When administered rapidly and completely absorbed.

The drug enters the body is subjected to intense biotransformation in the liver and leads to the formation of the active metabolite. In the process of metabolism of the substance excreted from the body. In order to achieve an erection the drug administered orally at a dose of 50 mg 1 hour before the scheduled intercourse. Doses vary depending on the desired effect. The maximum recommended dose is no more than 0.1 g 1 per day. According to available indications, the drug is generally well tolerated. Among the side effects of therapeutic agent are: dizziness, headache, increased peripheral vascular (flushing), indigestion, blurred vision, myalgia, and arthralgia.

There are also contraindications for use. The drug is not recommended in cases of severe medical conditions. Cardiologists pay attention to patients at risk of therapeutic agent in conjunction with nitrates. For patients who suffer from diabetes, endocrinologists recommended to consult with an ophthalmologist and a cardiologist.